The whole parish lies in an area of Best Landscape, with three sites of Natural History interest,

• Ermine St Wood (Grid Ref:271654),
• Lattenbury Hill Wood (Grid Ref: 268660,
• Meadows (Grid Ref: 268645).

The area is 1,298 acres. It used to extend to 1316 acres, but 18 of these were lost to Papworth Everard during modern boundary adjustments, which came into operation October 8th, 1904. 

Until 1895 some 586 acres in the N.E. lay in Huntingdonshire and the rest lay in Cambridgeshire, with the boundary running between the chimneys of the Manor.

The B1040 on the south-east is part of the county boundary on the south to the Nill Well where it follows the stream north to the Graveley road, and further north to the former county boundary of Huntingdonshire

On the east, Ermine Street (A1198) separates Papworth St Agnes from Hemingford Abbots and Hilton.

Nill Well is notable because it is a chalybeate spring meaning the water is impregnated with iron salts

The meadows between the brook and to the west of the houses are a conservation area which includes a site of Natural History Interest.